An Alternative Method for Determining the Radiochemical Purity of 99mTc-Tetrofosmin
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چکیده
منابع مشابه
An alternative method for determining the radiochemical purity of 99mTc-tetrofosmin.
The instant thin-layer chromatographic method of determining the radiochemical purity of (99m)Tc-tetrofosmin recommended by the manufacturer uses a mixture of acetone and dichloromethane (35:65 v/v) as the solvent and a silica gel (SG) strip as the solid phase. Currently, SG strips are not available commercially and an alternative solid phase is needed. The present study reports that silicic ac...
متن کاملDetermination of the radiochemical purity of 99mTc- tetrofosmin: Comparison between five methods
METHODS: Nineteen vials of tetrofosmin were radiolabelled with Tc and the percentages of the RCP were determined. Five different methods were compared with the standard RCP testing method (ITLC-SG, 2x20 cm): Whatman 3MM (1x10 cm) with acetone and dichloromethane (method 1); Whatman 3MM (1x10 cm) with ethyl acetate (method 2); aluminum oxide-coated plastic thin-layer chromatography (TLC) plate (...
متن کاملInfluence of Storage Temperature on Radiochemical Purity of 99mTc-Radiopharmaceuticals.
The influence of effective room temperature on the radiochemical purity of 99mTc-radiopharmaceuticals was reported. This study was born from the observation that in the isolators used for the preparation of the 99mTc-radiopharmaceuticals the temperatures can be higher than those reported in the commercial illustrative leaflets of the kits. This is due, in particular, to the small size of the wo...
متن کاملEvaluation of an alternative radiochemical purity testing method for technetium-99m sestamibi.
OBJECTIVE Our study evaluated the accuracy and reliability of 3 radiochemical purity (RCP) measurement methods of 99mTc-sestamibi. A regular-sized (1.0 cm x 9.0 cm) Whatman 31 ET Chr paper strip (regular 31 ET) also was included in our evaluation because of its ease in handling. METHODS The miniaturized and regular 31 ET methods were compared with the standard RCP testing method (aluminum oxi...
متن کاملAn enzymic radiochemical method for determining phosphatidylglycerol in amniotic fluid.
We describe an enzymic quantification of phosphatidylglycerol in amniotic fluid. Phosphatidylglycerol is hydrolyzed in alkali and the resulting glycerol is then enzymatically phosphorylated with adenosine 5'-[gamma-32P]triphosphate to yield glycero[32P]phosphate. After removal of excess [gamma-32P]ATP by charcoal, the radioactivity of the glycerophosphate is measured in a liquid scintillation c...
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ژورنال
عنوان ژورنال: Journal of Nuclear Medicine Technology
سال: 2011
ISSN: 0091-4916
DOI: 10.2967/jnmt.110.080788